2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1902):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-154017
    2′-C-Methyl-6-O-methylinosine
    2′-C-Methyl-6-O-methylinosine is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia.
    2′-C-Methyl-6-O-methylinosine
  • HY-152507
    N1-Methyl-2’-beta-C-methyl inosine
    N1-Methyl-2’-beta-C-methyl inosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N1-Methyl-2’-beta-C-methyl inosine
  • HY-154610
    6-Amino-9-[2-deoxy-β-D-ribofuranosyl]-9H-purine
    6-Amino-9-[2-deoxy-β-D-ribofuranosyl]-9H-purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    6-Amino-9-[2-deoxy-β-D-ribofuranosyl]-9H-purine
  • HY-154734
    N3-(4-Nitrobenzyl)uridine
    N3-(4-Nitrobenzyl)uridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents.
    N3-(4-Nitrobenzyl)uridine
  • HY-B1449S4
    Uridine-13C-3
    Uridine-13C-3 is the 13C labeled Uridine.
    Uridine-<sup>13</sup>C-3
  • HY-152362
    8-Hydroxy-3'-deoxy-3'-fluoroguanosine
    8-Hydroxy-3’-deoxy-3’-fluoroguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    8-Hydroxy-3'-deoxy-3'-fluoroguanosine
  • HY-152725
    N1-Benzyl pseudouridine
    N1-Benzyl pseudouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N1-Benzyl pseudouridine
  • HY-152592
    3’-Azido-3’-deoxy-beta-L-cytidine
    3’-Azido-3’-deoxy-beta-L-cytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 3’-Azido-3’-deoxy-beta-L-cytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    3’-Azido-3’-deoxy-beta-L-cytidine
  • HY-130803
    5-Methyl-5,6-dihydrouridine
    5-Methyl-5,6-dihydrouridine is a minor constituent in the chromosomal RNA of the rat ascites tumor. 5-Methyl-5,6-dihydrouridine can be used for nucleic acid modification.
    5-Methyl-5,6-dihydrouridine
  • HY-154154
    3,5-Bis-O-(4-methylbenzoyl)-2-C-methyl-D-ribonic acid gama-lactone
    3,5-Bis-O-(4-methylbenzoyl)-2-C-methyl-D-ribonic acid gama-lactone is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3,5-Bis-O-(4-methylbenzoyl)-2-C-methyl-D-ribonic acid gama-lactone
  • HY-149160
    5′-Amino-5′-deoxythymidine
    5′-Amino-5′-deoxythymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5′-Amino-5′-deoxythymidine
  • HY-152994
    1,2-Di-O-acetyl-3,5-di-O-benzoyl-D-xylofuranose
    1,2-Di-O-acetyl-3,5-di-O-benzoyl-D-xylofuranose is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    1,2-Di-O-acetyl-3,5-di-O-benzoyl-D-xylofuranose
  • HY-152580
    5-[3-[(2,2,2-Trifluoroacetyl)amino]-1-propyn-1-yl]uridine
    5-[3-[(2,2,2-Trifluoroacetyl)amino]-1-propyn-1-yl]uridine is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis. 5-[3-[(2,2,2-Trifluoroacetyl)amino]-1-propyn-1-yl]uridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    5-[3-[(2,2,2-Trifluoroacetyl)amino]-1-propyn-1-yl]uridine
  • HY-152367
    8-Hydroxy-3'-deoxyguanosine
    8-Hydroxy-3’-deoxyguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    8-Hydroxy-3'-deoxyguanosine
  • HY-154252
    2’,3’,5’-Tri-O-benzoyl-5-hydroxymethyl-2’-β-C-methyluridine
    2’,3’,5’-Tri-O-benzoyl-5-hydroxymethyl-2’-β-C-methyluridine is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
    2’,3’,5’-Tri-O-benzoyl-5-hydroxymethyl-2’-β-C-methyluridine
  • HY-111647R
    N2-Methylguanosine (Standard)
    N2-Methylguanosine (Standard) is the analytical standard of N2-Methylguanosine (HY-111647). This product is intended for research and analytical applications. N2-Methylguanosine is a commonly modified nucleoside in rRNA and tRNA, with specific distributions in both E. coli rRNA and eukaryotic tRNA. N2-Methylguanosine can be found in urine. N2-Methylguanosine affects the structure and stability of RNA.
    N2-Methylguanosine (Standard)
  • HY-152583
    3’-Azido-3’-deoxy-5-methyl-beta-L-uridine
    3’-Azido-3’-deoxy-5-methyl-beta-L-uridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 3’-Azido-3’-deoxy-5-methyl-beta-L-uridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    3’-Azido-3’-deoxy-5-methyl-beta-L-uridine
  • HY-154412
    N4-Benzoyl-2’-deoxy-2’-fluoro-β-D-arabinocytidine
    N4-Benzoyl-2’-deoxy-2’-fluoro-β-D-arabinocytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N4-Benzoyl-2’-deoxy-2’-fluoro-β-D-arabinocytidine
  • HY-154622
    N6-Bz-5’-O-DMTr-2’-O-hexadecanyl adenosine
    N6-Bz-5’-O-DMTr-2’-O-hexadecanyl adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N6-Bz-5’-O-DMTr-2’-O-hexadecanyl adenosine
  • HY-154354
    Methyl 3’-O-benzyl xyloriboside
    Methyl 3’-O-benzyl xyloriboside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    Methyl 3’-O-benzyl xyloriboside